UFC 165 is the first UFC pay-per-view to feature two title defenses since UFC 152, which also took place in Toronto.

The main event is expected to be a UFC Light Heavyweight Championship bout between the current champion Jon Jones and #1 contender Alexander Gustafsson.^[2][3][4]

Co-featured on the card will be a rescheduled Interim Bantamweight Championship bout between the current champion Renan Barão, and former WEC Bantamweight Champion and top contender Eddie Wineland.^[5] The pairing was first planned as the headliner at UFC 161, but was removed from that event after Barao had a foot injury.

Mark Bocek was expected to face Michel Prazeres at this event. However, Bocek pulled out due to an injury and was replaced by UFC newcomer Jesse Ronson.